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Creators/Authors contains: "Sugaya, Kiminobu"

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  1. ; ; ; (, 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC))
    Neuroblastoma cells are often used as a cell model to study Parkinson's disease, which causes reduced dopamine release in substantia nigra, the midbrain that controls movements. In this paper, we developed a 1024-ch monolithic CMOS sensor array that has the spatiotemporal resolution as well as low-noise performance to monitor single vesicle release of dopamine from neuroblastoma cells. The CMOS device integrates 1024 on-chip electrodes with an individual size of 15 μm × 15 μm and 1024 transimpedance amplifiers for each electrode, which are each capable of measuring sub-pA current. Thus, this device can be used to study the detailed molecular dynamics of dopamine secretion at single vesicle resolution. 
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  2. ; ; ; ; ; ; (, IEEE Transactions on Biomedical Circuits and Systems)
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